abstract：:Heparin-induced thrombocytopenia (HIT) is a prothrombotic condition and it is associated with increased in vivo thrombin generation that needs to be treated with non-heparin anticoagulants such as direct thrombin inhibitors (DTIs). DTIs require parenteral administration and are associated with a non negligible risk of...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Favaretto E,Cini M,Legnani C,Cosmi B

更新日期：2015-10-01 00:00:00

abstract：:Reticulated platelets (RP) are young, hyperactive platelets that are increased during situations of enhanced platelet turnover such as acute myocardial infarction (AMI). The dynamics of RP levels after AMI is not established. We aimed to characterize the levels of circulating RP over time in patients with AMI. Patient...

journal_title：Journal of thrombosis and thrombolysis

authors： Eisen A,Lerman-Shivek H,Perl L,Rechavia E,Leshem-Lev D,Zemer-Wassercug N,Dadush O,Kazum S,Codner P,Kornowski R,Lev EI

更新日期：2015-07-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) have a 1.5-3.5-fold higher risk of thromboembolism when compared to the non-IBD population and the risk is much more prominent at the time of a flare. Arterial thromboembolism (ischemic stroke, focal white matter ischemia, cardiac ischemia, peripheral vascular disease and...

journal_title：Journal of thrombosis and thrombolysis

authors： Kohoutova D,Moravkova P,Kruzliak P,Bures J

更新日期：2015-05-01 00:00:00

abstract：:Thromboembolism afflicts millions of patients annually in the United States and is associated with a significant cost burden. Recent advances in oral anticoagulation have provided clinicians with more options for management of these diseases. Accordingly, regulatory, legislative, and policy-making organizations have i...

journal_title：Journal of thrombosis and thrombolysis

authors： Fanikos J,Buckley LF,Aldemerdash A,Terry KJ,Piazza G,Connors JM,Goldhaber SZ

更新日期：2015-04-01 00:00:00

abstract：:We report a case of infective endocarditis (IE) involving the posterior mitral leaflet (PML) with calcific embolization in a patient with hypertrophic obstructive cardiomyopathy (HOCM). Amongst HOCM patients with IE, the anterior mitral leaflet and basal septal myocardium are almost always involved due to the endocard...

journal_title：Journal of thrombosis and thrombolysis

authors： Lather N,Niziolek K,Toth P,Harris DM

更新日期：2015-02-01 00:00:00

abstract：:The link between myeloma and thrombosis is well established. Monoclonal gammopathy of undetermined significance (MGUS) has also been associated with an increased risk of thrombosis. It was recently demonstrated that patients with myeloma display changes in thromboelastometry that may indicate a prothrombotic state. Th...

journal_title：Journal of thrombosis and thrombolysis

authors： Crowley MP,Quinn S,Coleman E,Eustace JA,Gilligan OM,O'Shea SI

更新日期：2015-02-01 00:00:00

abstract：:The objective was to compare the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity, as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known. This was a randomised, open-label, crossover PD/PK study of 40 Hispanic...

journal_title：Journal of thrombosis and thrombolysis

authors： Price MJ,Clavijo L,Angiolillo DJ,Carlson G,Caplan R,Teng R,Maya J

更新日期：2015-01-01 00:00:00

abstract：:A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cho...

journal_title：Journal of thrombosis and thrombolysis

authors： Platt DE,Ghassibe-Sabbagh M,Youhanna S,Hager J,Cazier JB,Kamatani Y,Salloum AK,Haber M,Romanos J,Doueihy B,Mouzaya F,Kibbani S,Sbeite H,Deeb ME,Chammas E,El Bayeh H,Khazen G,Gauguier D,Zalloua PA,Abchee AB,FGENTCA

更新日期：2015-01-01 00:00:00

abstract：:D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adve...

journal_title：Journal of thrombosis and thrombolysis

authors： Halaby R,Popma CJ,Cohen A,Chi G,Zacarkim MR,Romero G,Goldhaber SZ,Hull R,Hernandez A,Mentz R,Harrington R,Lip G,Peacock F,Welker J,Martin-Loeches I,Daaboul Y,Korjian S,Gibson CM

更新日期：2015-01-01 00:00:00

abstract：:The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS p...

journal_title：Journal of thrombosis and thrombolysis

authors： Fuentes B,Cruz-Herranz A,Martínez-Sánchez P,Rodríguez-Sanz A,Ruiz Ares G,Prefasi D,Sanz-Cuesta BE,Lara-Lara M,Díez-Tejedor E

更新日期：2014-11-01 00:00:00

abstract：:There is a significantly increased risk of pregnancy complications in women with anti-phospholipid syndrome (APS). The risk is further heightened in those with previous arterial or venous thromboembolism and so-called 'triple positivity' for anti-phospholipid antibodies (i.e., when lupus anticoagulant, and anti-cardio...

journal_title：Journal of thrombosis and thrombolysis

authors： Rose HL,Ho WK

更新日期：2014-11-01 00:00:00

abstract：:Prasugrel has been shown to be superior to clopidogrel in the setting of ACS patients undergoing coronary angioplasty. However, few data have been reported so far on those patients who switch from clopidogrel to prasugrel after coronary angioplasty. Aim of the current study was to evaluate the safety of prasugrel load...

journal_title：Journal of thrombosis and thrombolysis

authors： De Luca G,Verdoia M,Schaffer A,Suryapranata H,Parodi G,Antoniucci D,Marino P

更新日期：2014-10-01 00:00:00

abstract：:The REG2 Anticoagulation System consists of pegnivacogin, a subcutaneously administered aptamer factor IXa inhibitor, and its intravenous active control agent, anivamersen. Its effect on thrombin generation is unknown. A prospectively designed thrombin generation study was conducted within the phase 1 ascending dose s...

journal_title：Journal of thrombosis and thrombolysis

authors： Vavalle JP,Rusconi CP,Zelenkofske S,Wargin WA,Ortel TL,Alexander JH,Povsic TJ,Becker RC

更新日期：2014-10-01 00:00:00

abstract：:ABO dependent variation in von Willebrand factor (vWf) and procoagulant factor VIII (FVIII) is a plausible mechanism for modulating perioperative hemostasis and bleeding. Group AB has the highest and group O the lowest vWf and FVIII levels. Therefore, we tested the hypothesis that ABO blood group is associated with pe...

journal_title：Journal of thrombosis and thrombolysis

authors： Welsby IJ,Phillips-Bute B,Mathew JP,Newman MF,Becker R,Rao S,Milano CA,Stafford-Smith M

更新日期：2014-10-01 00:00:00

abstract：:The following manuscript presents two cases of ischemic stroke secondary to traumatic internal carotid artery thrombosis with concomitant middle cerebral artery thrombosis occurring very rarely in the medico-legal practice. Penetrating neck trauma due to an occupational accident and multiple head and neck trauma secon...

journal_title：Journal of thrombosis and thrombolysis

authors： Karnecki K,Jankowski Z,Kaliszan M

更新日期：2014-10-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) affects haemostasis and shifts its balance in favour of thrombosis. In vitro and in vivo studies suggested that HHcy may impair fibrinolysis either by influencing the plasma levels of fibrinolytic factors or by altering the fibrinogen structure. We investigated the influence of mild HHcy le...

journal_title：Journal of thrombosis and thrombolysis

authors： Cellai AP,Lami D,Antonucci E,Liotta AA,Rogolino A,Fedi S,Fiorillo C,Becatti M,Cenci C,Marcucci R,Abbate R,Prisco D

更新日期：2014-07-01 00:00:00

abstract：:To investigate the relationship between circulating microRNA 223 (miR-223) levels and clopidogrel responsiveness in patients with coronary heart disease. A total of 62 consecutive patients with troponin-negative non-ST elevation acute coronary syndrome (NSTE-ACS) scheduled for elective percutaneous coronary interventi...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang YY,Zhou X,Ji WJ,Shi R,Lu RY,Li JL,Yang GH,Luo T,Zhang JQ,Zhao JH,Jiang TM,Li YM

更新日期：2014-07-01 00:00:00

abstract：:Warfarin is the most widely prescribed oral anticoagulant, but large interindividual variations exist in the dose required to achieve comparable therapeutic effects. Several clinical and genetic variables have been identified that influence warfarin dosing. However, interactions between genotype and nutrition remain u...

journal_title：Journal of thrombosis and thrombolysis

authors： Saito R,Takeda K,Yamamoto K,Nakagawa A,Aoki H,Fujibayashi K,Wakasa M,Motoyama A,Iwadare M,Ishida R,Fujioka N,Tsuchiya T,Akao H,Kawai Y,Kitayama M,Kajinami K

更新日期：2014-07-01 00:00:00

abstract：:The CHADS(2) score is widely used to assess the risk of stroke in patients with atrial fibrillation (AF). Patients with score of 0 and 1 are considered 'low risk' and are often treated with aspirin. In a Danish Study, the CHA(2)DS(2)--VASc score was shown to identify low and high-risk subgroups among patients with CHA...

journal_title：Journal of thrombosis and thrombolysis

authors： Piyaskulkaew C,Singh T,Szpunar S,Saravolatz L 2nd,Rosman H

更新日期：2014-05-01 00:00:00

abstract：:Warfarin is among the ten drugs most commonly involved in adverse drug reactions, has a narrow therapeutic index and complex dosage regimen, exhibits enormous variability dose-response and high risk drug-drug interactions. To analyze the profile of pharmacoepidemiological drug prescriptions for warfarin in patients ad...

journal_title：Journal of thrombosis and thrombolysis

authors： Guidoni CM,Obreli-Neto PR,Pereira LR

更新日期：2014-05-01 00:00:00

abstract：:The dosage of warfarin is restricted due to its narrow therapeutic index, so, the required dose must be adapted individually to each patient. Variations in warfarin dosage are influenced by genetic factors, the changes in patient diet, anthropometric and clinical parameters. To determine whether VKORC1 G3730A and CYP4...

journal_title：Journal of thrombosis and thrombolysis

authors： Tatarunas V,Lesauskaite V,Veikutiene A,Grybauskas P,Jakuska P,Jankauskiene L,Bartuseviciute R,Benetis R

更新日期：2014-01-01 00:00:00

abstract：:The recent development and approval of novel oral anticoagulants represents a significant success in the intelligent design of target-specific therapeutics. However, while these agents obviate many of the shortcomings of their predecessor (warfarin), they present novel challenges in pharmacologic management as well. E...

journal_title：Journal of thrombosis and thrombolysis

authors： Steinberg BA,Becker RC

更新日期：2014-01-01 00:00:00

abstract：:Anticoagulation for the prevention of stroke is an important aspect of the management of atrial fibrillation. Novel anticoagulants including oral factor Xa inhibitors rivaroxaban and apixaban and the direct thrombin inhibitor dabigatran have emerged as important therapeutic treatment options for prevention of stroke i...

journal_title：Journal of thrombosis and thrombolysis

authors： DeWald TA,Becker RC

更新日期：2014-01-01 00:00:00

abstract：:Stroke and venous thromboembolism (VTE) are serious and preventable thrombotic events in patients with atrial fibrillation (AF) and who undergo surgery or hospitalization, respectively. Nevertheless, thromboprophylaxis remains greatly underused. The National Quality Forum, the Agency for Healthcare Research and Qualit...

journal_title：Journal of thrombosis and thrombolysis

authors： Eymin G,Jaffer AK

更新日期：2014-01-01 00:00:00

abstract：:Rivaroxaban is a direct factor Xa inhibitor, which is rapidly absorbed in the upper gastrointestinal (GI) tract. In large trials, it has been shown to be effective and safe in VTE treatment. However, in these trials patients with morbid obesity were not reported and it is unknown if the standard dosage of 20 mg rivaro...

journal_title：Journal of thrombosis and thrombolysis

authors： Mahlmann A,Gehrisch S,Beyer-Westendorf J

更新日期：2013-11-01 00:00:00

abstract：:Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elevation myocardial infarction. In a substudy, we aimed to determi...

journal_title：Journal of thrombosis and thrombolysis

authors： Povsic TJ,Najjar SS,Prather K,Zhou J,Adams SD,Zavodni KL,Kelly F,Melton LG,Hasselblad V,Heitner JF,Raman SV,Barsness GW,Patel MR,Kim RJ,Lakatta EG,Harrington RA,Rao SV

更新日期：2013-11-01 00:00:00

abstract：:We hypothesized that women are more prone to develop coronary dissections during PCI due to potential balloon-oversizing or gender specific plaque and vascular characteristics. To date, a gender related difference in edge dissection has not been systematically studied. The Massachusetts General Hospital Optical Cohere...

journal_title：Journal of thrombosis and thrombolysis

authors： Zeglin-Sawczuk M,Jang IK,Kato K,Yonetsu T,Kim S,Choi SY,Kratlian C,Lee H,Dauerman HL

更新日期：2013-11-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common arrhythmia in adults and contributes directly to adverse clinical events, ranging from ischemic stroke to heart failure and cardiovascular death. Because the incidence of AF and its attendant complications increase with age, there is a strong and growing need to develop safe...

journal_title：Journal of thrombosis and thrombolysis

authors： Bernacki GM,Becker RC

更新日期：2013-11-01 00:00:00

abstract：:Achieving therapeutic anticoagulation with warfarin is complicated by substantial inter-patient and intra-patient variability with numerous factors known to influence dose requirements. Obesity is one factor for which there remains no study to date investigating its initial effect on warfarin response assessed by INR,...

journal_title：Journal of thrombosis and thrombolysis

authors： Wallace JL,Reaves AB,Tolley EA,Oliphant CS,Hutchison L,Alabdan NA,Sands CW,Self TH

更新日期：2013-07-01 00:00:00

abstract：:Aortic stenosis (AS) accounts for the majority of valvular abnormalities requiring surgical intervention. Platelet dysfunction has been demonstrated among patients with severe aortic stenosis which may predispose patients to bleeding or ischemic events. Surgical aortic valve replacement (AVR) is the standard therapy f...

journal_title：Journal of thrombosis and thrombolysis

authors： Lynch DR Jr,Dantzler D,Robbins M,Zhao D

更新日期：2013-05-01 00:00:00

abstract：:Stroke and other thromboembolic events are mainly caused by emboli from heart, aorta and other arteries. In this paper we describe a group of 5 middle-aged patients suffering from emboli caused by large thrombi in the aorta. Since the development of giant thrombi under high flow conditions in the aorta is a pathophysi...

journal_title：Journal of thrombosis and thrombolysis

authors： Stoevesandt D,Klempt C,Scheubel R,Herr W,Hettwer S,Werdan K,Silber RE,Kraya T,Thews O,Schlitt A

更新日期：2013-02-01 00:00:00

abstract：:The anticoagulant properties of a novel RNA aptamer that binds FIXa depend collectively on the intensity of surface contact activation of human blood plasma, aptamer concentration, and its binding affinity for FIXa. Accordingly, anticoagulation efficiency of plasma containing any particular aptamer concentration is lo...

journal_title：Journal of thrombosis and thrombolysis

authors： Krishnan A,Vogler EA,Sullenger BA,Becker RC

更新日期：2013-01-01 00:00:00

abstract：:Argatroban is a parenteral direct thrombin inhibitor labeled for anticoagulation in patients with confirmed or suspected heparin-induced thrombocytopenia in the United States. Currently there are no studies evaluating bleeding risk factors in Intensive Care Unit patients.To determine bleeding risk factors associated w...

journal_title：Journal of thrombosis and thrombolysis

authors： Doepker B,Mount KL,Ryder LJ,Gerlach AT,Murphy CV,Philips GS

更新日期：2012-11-01 00:00:00

abstract：:Fondaparinux (FPX), a selective inhibitor of factor Xa, is widely used for the prophylaxis of venous thromboembolism (VTE) after total joint arthroplasty. However, the association between plasma FPX concentration and adverse events and the occurrence of VTE has not been clarified thus far. We aimed to prospectively ev...

journal_title：Journal of thrombosis and thrombolysis

authors： Yukizawa Y,Inaba Y,Watanabe S,Yajima S,Kobayashi N,Ishida T,Iwamoto N,Hyonmin C,Nakamura M,Saito T

更新日期：2012-11-01 00:00:00

abstract：:Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF), collectively known as Philadelphia-negative (Ph-negative) chronic myeloproliferative neoplasms (MPNs), MPNs represent the most common causes of splanchnic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and portal ve...

journal_title：Journal of thrombosis and thrombolysis

authors： Yonal I,Pinarbası B,Hindilerden F,Hancer VS,Nalcaci M,Kaymakoglu S,Diz-Kucukkaya R

更新日期：2012-10-01 00:00:00

abstract：:Arterial thrombosis is the leading causes of morbidity and mortality worldwide, whereas venous thrombosis is the most common preventable cause of hospital death. In either case, venous and arterial thrombosis should be considered autonomous entities, with only minor overlaps in terms of risk factors, predisposing cond...

journal_title：Journal of thrombosis and thrombolysis

authors： Lippi G,Favaloro EJ,Franchini M

更新日期：2012-10-01 00:00:00

abstract：:Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been exami...

journal_title：Journal of thrombosis and thrombolysis

authors： Claessen BE,Stone GW,Mehran R,Witzenbichler B,Brodie BR,Wöhrle J,Witkowski A,Guagliumi G,Zmudka K,Henriques JP,Tijssen JG,Sanidas EA,Chantziara V,Hakim D,Leon S,Xu K,Dangas GD

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study was to evaluate the association of prothrombotic gene polymorphisms [factor V Leiden (FVL) 1691GA, factor VII (FVII) 10976GA, FVII HVR4, platelet membrane glycoproteins GP1BA 1018CT, GP1BA VNTR, integrin ITGB3 1565TC, integrin ITGA2 807CT and methylenetetrahydrofolate reductase (MTHFR) 677C/T], p...

journal_title：Journal of thrombosis and thrombolysis

authors： Dogra RK,Das R,Ahluwalia J,Kumar RM,Talwar KK

更新日期：2012-08-01 00:00:00

abstract：:A significant proportion of the outcomes reported in trials assessing venous thromboembolism (VTE) prophylaxis in medical patients are related to asymptomatic events found on routine imaging studies. The implications of these events are controversial. Moreover, such trials did not always reflect the patient mix in tod...

journal_title：Journal of thrombosis and thrombolysis

authors： Vardi M,Steinberg M,Haran M,Cohen S

更新日期：2012-07-01 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) was studied as a marker of acute coronary syndrome (ACS). It has been shown that its levels are increased by heparin administration. Therefore, the aim of our study was to ascertain the diagnostic significance of PAPP-A in heparin-naïve patients and compare it with (TnI)....

journal_title：Journal of thrombosis and thrombolysis

authors： Hájek P,Macek M Sr,Pešková M,Hladíková M,Hansvenclová E,Malý M,Veselka J,Krebsová A

更新日期：2012-07-01 00:00:00